多相共存単分子膜中における脂質分布に及ぼすPoly(γ-methyl L-glutamate)の影響

概要

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Poly (γ-methyl L-glutamate) (PMLG) was added to mixtures of triolein (TO) and L-α-dilauroylphosphatidylcholine (DLPC). The mixtures were spread as insoluble monolayers at an air-water interface. PMLG caused phase separation in the monolayers and formed duplex films where PMLG was situated under polar groups of the lipid monolayers. In the mixed monolayers four transitions (a collapse of the lipid monolayer, a bilayer formation from PMLG monolayer, a formation of the duplex film and a transition of the duplex film) were observed and multiphases equilibria were found. From collapse pressures of lipid monolayers and formation pressures of the duplex films, lipid compositions in the lipid phases were estimated, and it was found that an increase in PMLG amount resulted in a decrease in TO concentration in the lipid phase being in equilibrium with the polymer phase or the duplex film. It was shown that PMLG caused unequal distribution of the lipids in the mixed monolayers.
公益社団法人日本薬学会の論文
1987-08-25