アスパラギン酸塩水溶液中におけるイオンの拡散およびウシ水晶体カプセルに対する膜透過

概要

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Aqueous electrolytic solution of a mixture of potassium hydrogen aspartate (KHAsp) and magnesium hydrogen aspartate [Mg(HAsp)_2] was examined for the dispersion behavior of each ion and penetration through the vitreous capsule of bovine eye. Dispersion coefficient of K^+ increased with increasing fraction of Mg^<2+> in the solution, indicating that Mg ion accelerated the dispersion of K ion, while dispersion coefficient of Mg^<2+> decreased with increasing fraction of K^+, indicating that K ion retarded the dispersion of Mg ion. This tendency was also observed in a mixed solution of KCl and MgCl_2 examined for the sake of comparison. Examination of the beavior of the solution with vitreous capsule indicated that the parameter f that expresses the interaction between the membrane and ion was greater in KHAsp-Mg(HAsp)_2-H_2O system than in KCl-MgCl_2-H_2O system, and there was a difference between K and Mg ions. It was found that the value of f_<MG> of Mg ion increased in the presence of KHAsp.
公益社団法人日本薬学会の論文
1972-10-25