懸濁粒子の沈積状態に関する物理化学的研究(第7報)導電率法によるピリミジンペニシリンGの沈積状態に関する研究

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The effect of primary particle radius (γ_0), addition of a polymer [po1y (vinylpyrrolidone), sodium carloxymethyl cellulose)], and centrifugal sedimentation on the sedimentation states of pyrimidine-penicillin G (PYG) were examined by the measurement of apparent aggregation degree (γ_m/γ_0,where γ_m is the apparent secondary particle radius), porosity (ε) and tortuosity (q) of the sedimentation bed, and the amount of polymers adsorbed on particles. The following results were obtained. 1) γ_m/γ_0 and ε did not change in parallel with each other while q and ε changed in the opposite direction with respect to the polymer concentration. 2) The effect of polymers on ε and difference in q with the direction of measurement were not found in the case of centrifugal sedimentation. 3) Saturated amount of adsorption X_∞ of the polymers was higher than the theoretical value which was calculated by assuming monlayer adsorption of the monomers. 4) Plots of the data to see the relation between q and (1-ε) gave straight line. 5) q_v/q_H decreased with increase in ε at γ_0= 1.8,8.9,and 13.2 μmz, and almost constant against ε at 2.9 and 4.8 μm.
公益社団法人日本薬学会の論文
1976-11-25