懸濁粒子の沈積状態に関する物理化学的研究(第6報)グリセオフルビンと炭酸カルシウムの凝集および沈積状態に及ぼすポリアクリル酸ナトリウムの作用について

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The effect of sodium polyacrylate on the aggregation and sedimentation states of griseofulvine (primary particle size γ_o of 1.2μ) and calcium carbonate γ_o(of 1.8μ) were studied, in the presence of sodium dodecyl sulfate (SDS), methylcellulose, polyoxyethylenesorbitane oleate (POE-SO), sodium chloride, or polyvinylpyrrolidone (PVP), by measuring degree of apparent aggregation γ_m/γ_o, amount of adsorption (X), and ζ-potential in the suspensions, and by measuring porosity (ε) and tortuosity (q) of the sedimentation bed. Reduced viscosity (ηsp/C) of PANa increased in the presence of MC and decreased in the presence of other additives. Values of γ_m/γ_o and ε showed a maximum on their plots against the concentration of PANa, at 0.0075 g/100 ml for GR, and at 0.005 g/100 ml for CaCO_3. This tendency was not affected by the coexisting materials. These values shifted to higher values by the addition of MC at 0.05 g/100 ml, and to lower values by the addition of other materials. Values of γ_m/γ_o.ε, and X decreased, and q and ζ-potential increased with the increase of pH. For both GR and CaCO_3,these quantities gave different values when the order of addition of PANa and SDS to the CaCO_3 suspension was changed. The adsorption isotherms of PANa on GR and CaCO_3 at 25° were of Langmuir type. The ζ-potential was increased with the increase of PANa concentration. In the graph showing the relation between ε and q, all plots fell on the same line. The ratio, of q_V/_H. which indicates the anisotropy of sedimentation bed, increased with the increase of ε, where qH is the horizonta tortuosity and qv is the vertical tortuosity.
公益社団法人日本薬学会の論文
1976-09-25

懸濁粒子の沈積状態に関する物理化学的研究(第6報)グリセオフルビンと炭酸カルシウムの凝集および沈積状態に及ぼすポリアクリル酸ナトリウムの作用について

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