懸濁性シロップ剤の物理化学的研究(第5報) : スルファミン類の界面動電位に対する粒度の影響について

概要

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The electrokinetic potential (ζ-potential) of sulfisoxazole, sulfadimethoxine, and N^1-acetylsulfisoxazole in aqueous solutions of sodium lauryl sulfate (SLS) was measured by the streaming potential method and the influence of particle size on the electrokinetic potential of these sulfanilamides was investigated. It was thereby recognized that the value of -ζ increased with the decrease of particle size, and it reached a maximum value at the 60-100 mesh samples and again decreased with a further decrease in particle size, although the influence of particle size on the ζ-potential does not appear in the Helmholtz-Smoluchowski's equation ζ=H/P・4πηκ/D. It was found that there is a maximum point in the cruve of-ζ vs. the particle size. The value of-ζ and saturated adsorption of SLS increased in the order of N^1-acetylsulfisoxazole > sulfadimethoxine > sulfisoxazole. This order was the same as the order of contact angle values, 56.4°, 50.2°, and 47.6°. It was concluded that the adsorption of SLS on sulfanilamides is ascribed to interaction between hydrophobic part of sulfanilamides and SLS molecule.
公益社団法人日本薬学会の論文
1968-02-25