懸濁性シロップ剤の物理化学的研究(第4報) : スルファミン類の界面動電位に対する界面活性剤の作用について

概要

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The electrokinetic potential (ζ-potential) of sulfisoxazole, sulfadimethoxine, and N^1-acetylsulfisoxazole in aqueous solution and in 10% sucrose solution was measured by the streaming potential method and the influence of sodium lauryl sulfate (SLS) and polyoxyethylene nonyl phenyl ether (PE-N) on the electrokinetic potential of these sulfanilamides was investigated. It was thereby recognized that ζ-potential was negative and its absolute value increased markedly with the increase of SLS concentration, and it had a maximum value at 4×10^<-3> mole/L. of SLS concentration. This is considered to be due to adsorption of SLS on sulfanilamide. The amount of adsorbed SLS was calculated according to the following equation : [numerical formula] where Δσ is the difference between the charge densities of the surface in the solutions, with and without SLS. It was found that the absorption of SLS on sulfanilamide is a Langmuir type. On the other hand, the absolute value of the negative ζ-potential of sulfanilamides decreased by addition of PE-N, although PE-N is a nonionic surface-active agent.
公益社団法人日本薬学会の論文
1966-04-25