懸濁性シロップ剤の物理化学的研究(第7報) : スルホンアミド類に対するポリオキシエチレンノニルフェニルエーテルの分散作用について

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The dispersibility of sulfisoxazole, sulfadimethoxine, and N^1-acetylsulfisoxazole in aqueous sucrose solutions (0-30%) in the presence of polyoxyethylene nonyl phenyl ether (PEN) (0.05-8.0×10^<-3> mole/liter) was examined on the basis of the apparent median radius (γ_<med>) as estimated from the particle size distribution obtained by the use of sedimentation balance, as well as the sedimentation volume and the amount of PE-N adsorbed on sulfonamides. It was found that the γ_<med> decresed markedly in a PE-N concentration range of 4-6×10^<-4> mole/liter, and showed a minimum at about 1×10^<-3> mole/liter, and that the sedimentation volume was also reduced markedly in the same conecntration range of PE-N and then levelled off. Influence of the presence of sucrose on γ_<med> and sedimentation volume was observed only with N^1-acetylsulfisoxazole, both of which increased with the sucrose concentration. From these results it was concluded that the dispersive sedimentation of sulfonamides began at the PE-N concentration of about 1×10^<-3> mole/liter, and the dispersibility rather decreased by the addition of sucrose. Correlation between dispersibility and amout of PE-N adsorbed on the sulfonamides was examined. It was found that the saturated amout of PE-N adsorbed on the sulfonamides was almost monolayer saturated adsorption, and the dispersive sedimentation began on the monolayer saturated adsorption.
公益社団法人日本薬学会の論文
1970-06-25

懸濁性シロップ剤の物理化学的研究(第7報) : スルホンアミド類に対するポリオキシエチレンノニルフェニルエーテルの分散作用について

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