粘度法によるコンドロイチン硫酸チトリウムとウシ血清アルブミンとの相互作用に関する研究

概要

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Viscosity measurements were carried out for the mixed solutions of bovine serum albumin and chondroitin sulfate of various mixing ratios in 0.01M sodium chloride solutions at 25°. Since the soluble complex was formed in this system, the intrinsic viscosity of the complex molecule [η]_m was calculated from the apparent intrinsic viscosity [η]_t which had been obtained experimentally by assuming that the solutions contained one solute whose concentration was the sum of the two solutea. The values of [η]_m thus obtained were compared with theoretical values of the intrinsic viscosity calculated for various models from the three quantities of the complex molecule, M_m, V_m, and R_<gm>, obtained by the light scattering studies as reported in the previous paper. It was concluded from these results that the prolate spheroid is the most suitable model for the complex molecules.
社団法人日本薬学会の論文
1973-09-25