懸濁粒子の沈積状態に関する物理化学的研究(第3報)ピリミジンペニシリンGの沈積状態に及ぼすポリアクリル酸ナトリウムの作用に関する研究

概要

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The effect of sodium polyacrylate (PANa) on the aggregation and sedimentation state of pyrimidine penicillin G (PYG) was examined by the measurement of the apparent degree of aggregation (γ_m/γ_0), amount of adsorption (X), ζ-potential, porosity (ε), and tortuosity (q) of the sedimentation layer. PYG of various primary particle radius (γ_0) and PANa of various molecular weight (Mη) were used as the sample. It was found that the adsorption isotherms of PANa on PYG were of Langmuir type. Amount of saturated adsorption (X_∞ : mg/g) increased with the increase of Mη and the decrease of γ_0. A little increase of X_∞ was found in the presence of NaCl. X_∞ in mg/cm^2 showed a little higher value with the decrease of γ_0. η-Potential increased with the increase of PANa concentration and decreased in the presence of NaCl. PYG forms secondary particles in water by aggregation and its γ_m/γ_0 and ε increased with the increase of PANa concentration and Mη. This tendency was more pronounced in the case of larger γ_0. The aggregation effect of PANa on PYG decreased in the presence of NaCl. q decreased and q_v/q_H increased with the increase of PANa concentration. It was concluded that the anisotropy of the sedimentation layer increased by the nonspherical nature of the aggregated secondary particle grown up by PANa.
公益社団法人日本薬学会の論文
1975-08-25