懸濁粒子の沈積状態に関する物理化学的研究(第1報)導電率法によるプロカインペニシリンGの沈積状態の研究

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The sedimentation states of procaine penicilline G (PPG) in the sedimentation bed was examined by the measurement of geometric parameters, prosity (ε) and tortuosity (q), the latter being calculated from the relative conductivity ratio (f). PPG powder crushed by Jet-O-Mizer was used as the sample. Aqueous solutions of various molecular weight (M^^-_η) of poly(vinylpyrrolidone)(PVP) and sodium carboxymethylcellulose (CMC-Na) after being saturated with PPG were used as the suspending medium at 25°. It was found that the sedimentation volume of PPG varied with the concentration and M^^-_η of PVP. Variations were, however rather little in the case of CMC-Na. The tortuosity (q) showed different values according to whether it was measured in the horizontal (qH) or in the vertical (qv) direction of the bed. It was also found that qH was greater than qv. All the data plotted to see the relation between q and ε fell on the same line, showing that q decreased with the increase of ε. In the case of glass sphere, both ε and q were almost constant and the rafio of qv/qH was equal to 1. There was little effect of particle concentration on ε and q of PPG in the sedimentation bed.
公益社団法人日本薬学会の論文
1973-02-25