リン脂質の多形に関する熱的研究(第2報)L-ジパルミトイルフォスファチジルエタノールアミンと水の混合系が示す多形

概要

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DSC curves of mixtures of synthetic L-dipalmitoyl phosphatidylethanolamine (DPPE) and water were measured for samples prepared in various conditions. The various kinds of phase transitions were detected and the values of transition temperature and transition enthalpy were obtained from the DSC curves. Between 30° and 145°, there are three lyotropic polymorphs, each with several thermotropic polymorphs. In the case of anhydrous DPPE, there is a quasi-stable noncrystalline solid phase which is easily annealed to a crystalline phase. In the case of mixtures, there are two hydrous forms of DPPE which have the hydration number of 1 and 8 respectively. On the basis of these results, the phase diagram of DPPE-water system was drawn.
社団法人日本薬学会の論文
1979-06-25