ジパルミトイルレシチンーコレステロール混合単分子膜へのトリフルペラジンの侵入

概要

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Penetration of trifluoperazine (TFPeZ), a phenothiazine tranquilizer, into mixed monolayers of dipalmitoyl lecithin (DPL) and cholesterol (CH) was studied by measurement of surface pressure (F)-mean molecular area (A^^^-_<34>) curves. The amount of penetration (or adsorption) by TFPeZ was calculated by the modified Gibbs adsorption equation. Adsorption isotherms at a constant A^^^-_<34> showed a type of Langmuir adsorption. Saturated amount of adsorption (Γ^<∞>_2) and Langmuir constant (k) were obtained by Langmuir plots. Correlation between those parameters and A^^^-_<34> at various mixing ratios of DPL and CH were discussed. With decreasing A^^^-_<34>, Γ^<∞>_2 decreased in any DPL-CH mixed monolayer. The relation between Γ^<∞>_2 and composition of the monolayer at a constant A^^^-_<34> corresponded well with the state of mixed monolayer, i.e. Γ^<∞>_2 is small in expanded monolayer rich in DPL (X_<DPL>>X_<CH>), and increases with decreasing X_<DPL> down to X_<DPL>=0.5. This increase corresponds to changes of the mixed monolayer state, from liquid expanded to solid condensed state. Below X_<DPL>=0.5,in which the mixed monolayer is fully solid, Γ^<∞>_2 level is independent of the monolayer composition. Miscibility of penetrated TFPeZ with insoluble components, DPL and CH, was also discussed.
公益社団法人日本薬学会の論文
1979-10-25