Competitive Adsorption of Phosphate Ion with Chondroitin Sulfate Ion and Its Effect on the Dispersion of Hydroxyapatite

概要

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The amounts of concurrent adsorption of anionic species, i.e., chondroitin sulfate (Chs) and phosphate (Pi), to synthesized hydroxyapatite (HAP) were determined. The amount of adsorption of Chs decreased with increasing concentration of Pi added. On the other hand, the adsorption of Pi was not inhibited in the presence of Chs. The affinity of HAP for Pi, one of the lattice ions, is significantly greater than that for Chs. Such a specific adsorption seems favorable for crystal growth in solutions containing various kinds of solutes and/or in the body fluids. The optical density (O.D.) of the HAP suspension, as an index of the suspension stability, was measured at 550nm. The contour lines of the O.D. as a function of the concentrations of Pi and Chs showed that Chs, coexisting with Pi, exhibits a dispersing and protecting effect on the HAP suspension except at high concentrations of both Pi and Chs. It was concluded that Chs affects the formation of secondary particles of HAP (i.e., aggregation and disaggregation), but does not affect the formation of the primary particles or the crystal growth of HAP through the selective adsorption of the lattice ions.
公益社団法人日本薬学会の論文
1984-04-25