Interaction of Cationic Surfactant with Arabate and Chondroitin Sulfate(Physical,Chemical)

概要

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Interactions of cationic surfactants with a branched polymer, arabate (Ar), and a linear polymer, chondroitin sulfate (Chs), were investigated by the potentiometric technique using surfactant ion-selective electrodes. The results indicated a highly cooperative nature in the binding process of n-dodecyltrimethylammonium ion (DOTMA^+) with Chs, but not Ar, in spite of the similarity of the charge density parameter, ξ, between the two polymers. The cooperativity parameter, u, was estimated from the Zimm-Brag theory in the present experimental system to be 3.5for Ar and 200 for Chs, each of which was independent of the concentration of added salt. The binding constant, K, in the case of the Chs-DOTMA^+ system was considerably larger than that of the Chs-DOTMA^+ system. This difference of binding behavior of DOTMA^+ to Ar and to Chs was considered to be mainly due to the structural difference between the two polymers.
公益社団法人日本薬学会の論文
1987-02-25