Microenvironment around Thiacarbocyanine Dyes in Lysolecithin Micelles, Surfactant Micelles and Lecithin Liposomal Membranes
スポンサーリンク
概要
- 論文の詳細を見る
The microenvironments provided by lysolecithin micelles, surfactant (heptaethylene glycol dodecyl ether, cetyltrimethylammonium chloride, sodium dodecyl sulfate and dodecyl sulfobetaine) micelles and lecithin liposomal membranes in aqueous solutions were investigated by using dialkylthiacarbocyanine dyes as spectroscopic (absorption and fluorescence) probes. These probes give information concerning effective polarity and effective viscosity in the vicinity (microenvironment) of the probe in liposomal membranes and micelles. The microenvironment of the cyanine dyes in lysolecithin micelles have higher polarity (corresponding to that of ethanol) and lower viscosity (3-10cP) than those of other surfactant micelles and lecithin liposomal membranes. The microenvironment provided by lecithin liposomal membranes has medium polarity (1-propanol) and the highest viscosity (10-65cP) among the three kinds of amphiphilic molecular aggregates. Surfactant micelles provide microenvironments with a wide range of polarity (corresponding to ethanol, 1-propanol or 1-butanol) and lower viscosity (2-8cP) than lecithin liposomal membranes. Thus, these molecular aggregates provide microenvironments of various polarities and viscosities, and a microenvironment suitable for solubilizing and stabilizing particular drugs can be provided by choosing appropriate molecular aggregates.
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
-
中垣 正幸
Faculty of Pharmaceutical Sciences, Kyoto University
-
半田 哲郎
京大・薬
-
中垣 正幸
東京コロイド科学研究所
-
半田 哲郎
Gifu Pharmaceutical University
-
小松 裕明
Faculty of Pharmaceutical Sciences, Kyoto University
-
小松 裕明
Division Of Drugs Osaka Branch National Institute Of Health Sciences
-
中垣 正幸
Tokyo Insitute Of Colloid Science
関連論文
- Examination of the Reaction Products in the Aqueous-Phase Preparation of Hydrated Calcium Diphosphates
- Flocculation and Formation of Open Structure of Kaolinite Suspension in the Presence of Polyvinylpyrrolidone
- Quantitative Analysis of Hemolytic Action of Lysophosphatidylcholines in Vitro : Effect of Acyl Chain Structure
- 光化学反応増感剤のジアルキルチアカルボシアニンの蛍光収率に対するミクロ環境の効果
- 歴代会長が語る膜学会と膜研究
- 合成基質法による低分子量ヘパリンの抗凝血活性の評価.ファクターXa及びトロンビン活性の測定
- Determination of the Molecular-Weight Distribution of Low-Molecular-Weight Heparins Using High-Performance Gel Permeation Chromatography
- Computer Simulation of Agglomeration by a Two-Dimensional Random Addition Model. IV. : Agglomeration Kinetics and Micromeritic Properties of Agglomerate of Binary Mixtures of Adhesive Circles
- 脂質膜から生体膜へ(生体膜研究の展望)
- TNSの蛍光測定に基づくウシ赤血球膜へのカチオンの結合性
- テトラフェニルポルフィリン誘導体により増感されるアゾ色素の光還元に対するミセルの環境の効果
- イオン性, 非イオン性界面活性剤の臨界ミセル濃度における活動度とミセル形成の自由エネルギーに対する構造の効果
- PATICIPATION OF OXYGEN IN PHOTODEGRADATION OF METHYL ORANGE IN MICELLAR SOLUTION
- Effect of Micellar Environment on the Photoreduction of Azo Dyes Sensitized by Tetraphenyl Porphyrin Derivatives
- TNSの螢光測定に基づくウシ赤血球膜へのカチオンの結合性
- 脂質膜での二量化する陽イオン性色素の存在部位と微小な環境に関する吸収スペクトル的研究
- ウシ赤血球のカリウム透過性変化と膜電位変化に関する二量化する蛍光プローブによる研究
- Changes in Potassium Permeability and Membrane Potential of Bovine Red Blood Cells estimated by the Use of a Dimerizing Fluorescence Probe
- Lyophilized Liposomes Prepared by a Modified Reversed-Phase Evaporation Method(Pharmaceutical)
- Crystal Modification of Phenytoin with Polyethylene Glycol for Improving Mechanical Strength, Dissolution Rate and Bioavailability by a Spherical Crystallization Technique
- The Effects of Thickness and Hardness of the Coating Film on the Drug Release Rate of Theophylline Granules Coated with Chitosan-Sodium Tripolyphosphate Complex
- Preparation of a Prolonged Release Tablet of Aspirin with Chitosan
- INTERACTION OF β-CYCLODEXTRIN WITH BILE SALTS IN AQUEOUS SOLUTIONS
- 無定形シリカの粒子表面細孔および一次粒子間間隙に浸入する水によって引き起こされるポリビニルピロリドン共存下でのコンドロイチン-6-硫酸ナトリウムおよびナトリウムカルボキシラトメチルセルロースの見かけの負吸着
- Interactions of Aspartic Acid, Alanine and Lysine with Hydroxyapatite
- Decrease in the Solubility Product of Hydroxyapatite by the Adsorption of Surface-Active Ion
- Adsorption of Cetylpyridinium and Cetyltrimethylammonium Ions on Hydroxyapatite and Concurrent Release of Phosphate and Calcium Ions from the Surface of Hydroxyapatite(Physical,Chemical)
- Effect of Added Salt on the Adsorption of Dodecyl Sulfate Ion and Concurrent Release of Phosphate and Calcium Ions at the Surface of Hydroxyapatite(Physical,Chemical)
- Adsorption of Dodecyl Sulfate Ion on Hydroxyapatite and Concurrent Release of Phosphate and Calcium Ions from the Surface of Hydroxyapatite
- Adsorption of Phosphate Ion by Hydroxyapatite in Water
- Effect of the Solubilized State of Tetraphenylporphyrin as a Photosensitizer on the Photooxidation of Methyl Orange in Sodium Dodecyl Sulfate Solution
- Effect of Sodium Dodecyl Sulfate Concentration on Photooxidation of Methyl Orange Sensitized by Tetraphenylporphyrin
- 脂質の界面化学的性質--バイオ機能の決め手
- 薬学における脂質エマルションの展望
- 血漿アポリポ蛋白質による脂質粒子表面のレシチン単分子膜と2分子膜の認識と差別化
- Effects of Cholesterol on the Miscibility of Synthetic Glucosamine Diesters in Lipid Bilayers and the Entrapment of Superoxide Dismutase into the Positively Charged Liposomes
- Pharmaceutical Characterization of Commercially Available Intravenous Fat Emulsions : Estimation of Average Particle Size, Size Distribution and Surface Potential Using Photon Correlation Spectroscopy
- Surface Tension of Aqueous Solutions of Prostaglandins and Related Unsaturated Fatty Acids
- Interaction of p-Hydroxybenzoic Acid Esters with Polyethylene Glycol
- Interaction of Propyl p-Hydroxybenzoate with Polyoxyethylene Dodecyl Ethers
- Estimation of Cation Binding of Arabate by Conductivity Measurement(Physical,Chemical)
- Interaction of Cationic Surfactant with Arabate and Chondroitin Sulfate(Physical,Chemical)
- アラビン酸塩の電場下での対イオン結合性
- The Molal Osmotic Coefficients and Counterion Activity Coefficients of Arabate with Various Counterions
- エマルション表面膜の脂質組成とリポタンパク質リパーゼ活性
- エマルション表面膜の構造変化によって制御されるアポリポ蛋白質の結合性 : スフィンゴミエリン及びコレステロールの影響
- Comparative Estimation of the Liposomal Content of Phosphatidylcholine : Triolein Emulsions Using Fluorescence Quenching and ^1H-NMR Techniques
- Interactions of Lecithin and Pig Apolipoproteins of High Density Lipoproteins at the Surface Monolayer of Reconstituted Very Small Particles
- Microenvironment around Thiacarbocyanine Dyes in Lysolecithin Micelles, Surfactant Micelles and Lecithin Liposomal Membranes
- Estimation of Critical Micelle Concentrations of Lysolecithins with Fluorescent Probes
- 増感剤として, 3,3'-ジアルキルアカルボシアニンを用いた光酸化還元反応の対する界面活性剤ミセルの効果
- Hydrolysis of Diphosphate Ion to Orthophosphate Ion in the Presence of Calcium Ion. Fundamental Study of the Development of the Mixed Crystal Deposition Disease(Physical,Chemical)
- 8-アニリノ-1-ナフタレンスルホン酸アンモニウム蛍光法による負荷電混合ミセルの表面電位
- 水溶液中におけるグリチルリチンの物理化学的性質(第5報)グリチルリチンとコール酸ナトリウムとの混合溶液の臨界ミセル濃度
- Application of Thermogravimetry to Water-Content Determinations of Drugs
- Effect of Temperature on the Surface Properties of Aqueous Solution of Arachidonic Acid
- Experimental Verification of the Theory of Membrane Potential for Collodion Membranes with Asymmetric Charge Distribution
- ホスファチジルイノシト-ルを含むレシチン・コレステロ-ル混合リポゾ-ムに対するホスホリパ-ゼDの作用
- ジミリストイルホスファチジルコリン/コレステロ-ルリポゾ-ムに対するホスホリパ-ゼDの作用
- Distribution of Acetylcholine Chloride between the Micellar and Bulk Phases as Studied by Ultrafiltration
- Theoretical Study on Asymmetric Membrane Potential
- 膜電位に対するHendersonモデルとGoldmanモデルの比較
- Light Scattering Titration of Lens Proteins
- Factors Affecting the Bioadhesive Property of Tablets Consisting of Hydroxypropyl Cellulose and Carboxyvinyl Polymer
- Membrane Potential and Permeability Coefficient of Cellulose Membrane dyed with Congo Red
- Physicochemical Studies on Calcium Glycerophosphate. I. X-Ray Diffraction Study of Calcium Glycerophosphate Crystals and Their Water of Crystallization
- Conformational Analysis of Glycerophosphate
- Effect of Saccharides on the Freezing and Thawing of Liposome Dispersion
- COMPLEX FORMATION BETWEEN DI-AND MONOPHOSPHATIDYLCHOLINES AND CYCLODEXTRINS IN WATER
- Competitive Adsorption of Phosphate Ion with Chondroitin Sulfate Ion and Its Effect on the Dispersion of Hydroxyapatite
- Hydrolysis of Diphosphate Ion to Orthophosphate Ion and Formation of Hydroxyapatite in the Aqueous Phase
- Interaction of Short-Chain Alkylammonium Salts with Cyclodextrins in Aqueous Solutions(Physical,Chemical)
- シクロデキストリンと脂質膜との相互作用 (分子認識とその応用) -- (基礎的解析と選択的反応)
- Micelle Formation of Polyoxyethylene Cholesteryl Ether in Water
- D-グルコ-ス-塩化カルシウム-水系およびD-グルコ-ス-グアニジニウム=ブロミド-水系の混合による自由エネルギ-変化
- Counter-Ion Dissociation of Chondroitin Sulfate Adsorbed on Hydroxyapatite in Water
- リン脂質と中性脂質の相互作用と構造形成について
- Decrease in Intrinsic Viscosity of Polyvinylpyrrolidone in the Presence of Sodium Chondroitin Sulfate or Sodium Carboxymethylcellulose in an Aqueous Solution
- 生体膜と人工膜
- 膜系としての泡
- コロイド科学の歩み--グレアムから計算コロイド科学まで
- ヒドロキシアパタイトに対するシュウ酸イオンの吸着とその吸着量におよぼす添加物の影響
- 光化学反応増感剤のジアルキルチアカルボシアニンの蛍光収率に対するミクロ環境の効果 (光化学反応とその応用)
- ヒドロキシアパタイトの分散性に及ぼすコンドロイチン硫酸イオンとカルシウムイオンの添加の影響
- Concurrent Binding of Calcium Ion and Chondroitin Sulfate Ion to the Surface of Hydroxyapatite
- リン脂質と中性脂質の相互作用と構造形成について
- Effect of Condensed Phosphate on the Precipitate Formation and Dispersion of Calcium Phosphate in Water
- Effect of Chondroitin Sulfate on the Precipitate Formation of Calcium Phosphate in Water
- Concurrent Adsorption of Calcium Ion and Hydroxyl Ion on Hydroxylapatite
- オクテット
- 生体膜機能のシミュレ-ション (生体膜と高分子膜--薄層に秘める高次機能)
- ヒドロキシアパタイトに対する塩化セチルピリジニウムの吸着
- Adsorption of Hydroxyl Ion on Hydroxyapatite
- Adsorption of Mono-and Divalent Metal Cations on Hydroxyapatite in Water