Pharmaceutical Characterization of Commercially Available Intravenous Fat Emulsions : Estimation of Average Particle Size, Size Distribution and Surface Potential Using Photon Correlation Spectroscopy
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概要
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Particle profiles such as the average diameter, size distribution and dispersion, as well as the zeta potential, of commercially available intravenous fat emulsions of high-calorie nutrient fluids (6 products) and drug carriers (4 products) were examined using photon correlation spectroscopy (dynamic light scattering). Wide variations were observed in number-weighted (dn), weight-weighted (dw) and z-average diameters, and dw/dn ratios as a measure of polydispersity. Average size is not sufficient for the pharmaceutical characterization of particles and the determination of size distribution or dw/dn value is essential for more precise information. Although measuring the zeta potential of fat emulsions is of considerable value in estimating their stability on long-term storage, a medium which accurately reflects the environment of the droplets in the system of interest should be chosen when diluting the emulsion.
- 1995-08-15
著者
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小松 裕明
Division of Drugs, National Institute of Health Science, Osaka Branch
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岡田 敏史
Division of Drugs, National Institute of Health Science, Osaka Branch
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岡田 敏史
国立衛研・大阪
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Okada S
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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小松 裕明
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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北島 文
Division of Drugs, Osaka Branch, National Institute of Health Sciences
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北島 文
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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Okada Satoshi
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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