フェノチアジン系向精神薬に関する研究(第1報) : 水溶液中の導電率

概要

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In order to clarify the behavior of phenothiazine hydrochlorides (PTZ・HCl) as electrolytes in aqueous solution, electric conductivity of their aqueous solutions was measured at 5,15,25,and 35°. Below the concentration of 10 mmol/liter, equivalent conductivity as a function of square root concentration of PTZ・HCl followed the Fuoss-Onsager limiting law. In this low concentration, all the PTZ・HCls were completely dissociated into each ion and behaved as a strong electrolyte of 1 : 1 valency type. In a higher concentration up to about 100 mmol/liter, a clear break point was observed on the curve of k-c or A-√<c> plot of each PTZ・HCl, except for chlorpromazine sulfoxide・HCl. This point was suggested to correspond to the critical micelle concentration (CMC) of surface-active agents. From the value of CMC and the degree of ionization of each aggregate, thermodynamic quantities of aggregation were calculated. It was interpreted that entropy effect associated with the destruction of icebergs around PTZ・H+ ion may play an important role in the aggregation, but enthalpy effect also shares a considerable contribution to the process, which was especially remarkable for chlorpromazine・HCl and triflupromazine・HCl.
公益社団法人日本薬学会の論文
1977-05-25