フェノチアジン・二塩酸塩水溶液の導電率

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Electric conductivity in aqueous solutions of two phenothiazine (PTZ) dihydrochlorides, which are fluphenazine (FPZ)・2HCl and perphenazine (PPZ)・2HCl, and of hydroxyzine (HXZ)・2HCl, which is not phenothiazine (Table IV), was measured at various temperatures in order to elucidate the aggregation of diprotonated phenothiazine (PTZH_2^<2+>). The plots of Λ-(I)^1/^2 showed upper shifts from the estimated value. From the concentration dependence of pH for their salt (B・2HCl) solutions, it was observed that this upper shift was the result of acid dissociation of BH_2^<2+> ion. By the determination of the first acid dissociation constant (pK_a), concentration of each ionic species at a salt concentration was calculated, and limiting equivalent conductivity, λ_1°, of BH^+ and BH_2^<2+> ion was estimated by Stokes'law. Total specific conductivity, k, of the solutions were estimated by Eq. (6), assuming that the present salt solutions were composed of 3 kinds of strong electrolytes, B・2HCl, B・HCl, and HCl. The concentration dependence of k for FPZ・2HCl solutions at various temperatures agreed well with the calculated ones, if λ°_<FPZH2>^<2+> were estimated to be 2 times of λ°_<FPZH>^+. On aqueous FPZ・2HCl and PPZ・2HCl solutions, apparent critical micelle concentration (cmc') was determined by a break point in the pH-concentration plots. Based on the assumption that each aggregate was composed of monoprotonated phenothiazine (PTZH^+) alone, cmc of each PTZH^+ was estimated. It was suggested that the estimated cmc was reasonable in comparison with that of chlorpromazine and triflupromazine.
公益社団法人日本薬学会の論文
1979-06-25

フェノチアジン・二塩酸塩水溶液の導電率

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