Estimations of Average Particle Sizes and Size Distributions of Commercially Available Human-Insulin Aqueous Suspensions Using Laser-Light Diffraction Spectroscopy
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概要
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The average diameter and size distribution of particles in commercially available isophane-insulin and zincinsulin aqueous suspensions (11 products) were examined using laser-light diffraction spectroscopy (LLDS). Wide variation was observed between products in volume-weighted and number-weighted average diameters. The particles in the insulin aqueous suspensions were found to be mono-dispersed within relatively narrow size distributions.Sonication for a short time led to a downshift in the apparent average diameter, which was most remarkable with isophane-insulin aqueous suspensions. This could be ascribed to dispersion of aggregated needle-like crystals and/or crystal breakage. In the case of biphasic isophane-insulin aqueous suspensions, the average size as well as the size distribution shifted toward the smaller end of the scale with decrease in the isophane content.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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OKADA Satoshi
Division of Drug Evaluation, National Institute of Health Sciences
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Nakata Y
Product Planning Department Horiba Ltd.
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Kitajima Aya
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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KOMATSU Hiroaki
Division of Drugs, Osaka Branch, National Institute of Health Sciences
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NAKATA Yasushi
Product Planning Department, Horiba, Ltd.,
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Komatsu Hiroaki
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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Okada Satoshi
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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Okada Satoshi
Division Of Drug Evaluation National Institute Of Health Sciences
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