Interactions of Lecithin and Pig Apolipoproteins of High Density Lipoproteins at the Surface Monolayer of Reconstituted Very Small Particles
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概要
- 論文の詳細を見る
Cosonication of egg yolk lecithin and triolein with apolipoproteins isolated from pig high density lipoprotein (apoHDL) gave us reconstituted high density lipoprotein particles (r-HDLs) of 9 nm in average diameter. They were smaller than microemulsion particles (MEs) composed of the lipids (35 nm). The protein/ egg yolk lecithin ratio in the fractionated r-HDLs was higher in the smaller particles. Binding of a hydrophobic probe, 2-p-toluidinylnaphthalene-6-sulfonate (TNS), to MEs, r-HDLs and apoHDL were evaluated on the basis of Halfman and Nishida's method. The reconstitution of apoHDL into MEs led to a 68% reduction in the binding of TNS and a small increase in the α-helix content as compared with free apoHDL. The binding experiments also showed the condensation of lecithin molecules at the r-HDL surface. The amphipathic helixes of apoHDL are located in the surface monolayer of egg yolk lecithin surrounding the triolein core. The intercalation of the hydrophobic residues of apoHDL between egg yolk lecithin molecules brings about a pronounced curvature of the surface and a decrease in the particle diametri.
- 公益社団法人日本薬学会の論文
- 1990-08-25
著者
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宮嶋 孝一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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半田 哲郎
京大・薬
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半田 哲郎
Faculty of Pharmaceutical Sciences, Kyoto University
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宮嶋 孝一郎
大阪薬科大学招聘教授
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半田 哲郎
Faculty Of Pharmacy Kyoto University
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小松 裕明
Faculty of Pharmaceutical Sciences, Kyoto University
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宮嶋 孝一郎
京大・薬
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掛江 敦之
Faculty of Pharmaceutical Sciences, Kyoto University
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宮嶋 孝一郎
京都大学薬学部
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小松 裕明
Division Of Drugs Osaka Branch National Institute Of Health Sciences
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宮嶋 孝一郎
Faculty Of Pharmaceutical Sciences Kyoto University
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掛江 敦之
Faculty Of Pharmaceutical Sciences Kyoto University
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