脂質膜の形成とミクロ環境

概要

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Phospholipids show lyotropic polymorphism. When increasing amount of water is added to dry lecithin, bilayer membrane structure is developed. The colloidal stabilities of membrane, the equilibriums between bilayer and monolayer membranes and the micibilities of lipid components in membrane are investigated for lipids and lipid-polypeptide mixtures. It is found that the water-lipid and lipid-lipid interactions and the thermotropic polymorphisms play important roles in the structure formations of membrane.<BR>Effective polarities and viscosities of close vicinity of amphiphilic probe in lipid membrane and micelle are evaluated on the basis of spectroscopic measurements of the probes. The results clearly show the structural differences between lipid membranes (liposomes) and micelles. Photo-sensitized electron transfers and activations of oxygen are studied in the lipid membrans and micelles, and correlated with the microenvironmental effects (effective polarities and viscosities) in the lipid molecular assemblies.
日本膜学会の論文