エマルション-溶媒-拡散法による薬剤粉末の球形晶析造粒の挙動, プロセスの改良及び回分式閉回路システムの提案

概要

論文の詳細を見る
Agglomeration mechanism of the spherical crystallization of a water soluble drug by the emulsion solvent diffusion method was investigated with a mixed system of two or three partially miscible solvents, i. e., bridging liquid-poor solvent system or good solventbridging liquid-poor solvent system. When bridging liquid (or plus good solvent) solution of the drug was poured into poor solvent (=dispersing medium) under agitation, quasi emulsion droplets of bridging liquid or good solvent were produced. The diffusion of bridging liquid or good solvent from the emulsion droplet into the dispersing medium induced the crystallization of drug, which was clearly monitored by an X-ray diffraction analysis. Seeding the drug crystals to the system enhanced the solidification of emulsion droplets, resulting improved agglomeration. The agglomerated crystals had the most thermodynamically stable crystalline form. Both hydrophilic and hydrophobic polymers could be coprecipitated into the agglomerated crystals to modify the physicochemical properties of raw crystals of the drug. A closed circuit batch operation system was proposed to use repeatedly the dispersing medium recovered after each operation for industrialization.
公益社団法人日本薬学会の論文
1991-08-25