噴霧乾燥造粒に関する研究(第7報)カプセル化サリチル酸の溶出速度

概要

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Based on the fact that inclusion of a suitable binder into feed liquid and drying of a sprayed droplet in a drying chamber results in an agglomerated or encapsulated particle, salicylic acid was encapsulated or agglomerated with acacia by the spray-drying technique and dissolution rate of the encapsulated particle was examined. The rapid dissolution rate of encapsulated salicylic acid indicated that coated film of the encapsule was not hardened but rather permeable. The apparent dissolution rate constant was decomposed into the particle internal mass transfer coefficient and the diffusion layer mass transfer coefficient by the "three-film model" which represents a general dissolution process of micro-encapsule. Spray-dried encapsule prepared from slurries having a lower concentration ratio of acacia to salicylic acid than 0.2 was found to be encased with a porous film by scanning electron microscopic observation and by the dissolution rate analysis. It was found that acacia equivalent to or more than salicylic acid should be included into the feed liquid in order to obtain a well-coated spray-dried capsule and the particle internal mass transfer coefficient is linearly correlated with the reciprocal of encapsulating film thickness of non-porous encapsule.
公益社団法人日本薬学会の論文
1977-04-25