薬剤粉体の充填性(第6報)薬剤粉体の充填における緻密化とバラツキの関係

概要

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Relationship between compacting progress of pharmaceutical powder and measurement variation of apparent density in the case of compacting phenomenon by means of tapping and compacting phenomenon in course of mixing with 1% calcium stearate was examined. At the beginning of compacting of a powder, measurement variation of apparent density decreased with progress of compacting, and their relationship was shown by experimental equation (1). σ_N/ρ_N×100=κ_1 log △ε_N+κ_2(1) where N is progress of compacting, i.e., number of tapping or cumulative revolution of the mixer, ρ_N is the mean value of measured apparent density, σ_N is standard deviation, △ε_N is differential change of porosity between compacting progress N and N+1,and κ_1 and κ_2 are experimental constants. After a certain degree of compacting progress, σ_N/ρ_N×100 did not decrease with decrease of log △ε_N, but became constant. This was considered to be an unavoidal experimental error. σ_N/ρ_N×100=κ_3 (2) Experimental constant κ_3 was thought to change according to the apparatus for measurement, powder, and other conditions. Equation (2) did not apply when abnormal phenomenon, such as segregation of particles in tapping, was likely to occur.
社団法人日本薬学会の論文
1976-01-25