滑沢剤の配合による粉体の見掛け密度の変化

概要

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Generally, lubricants are added into pharmaceutical powders in order to improve their fluidity, packing property and others. The present experiment was carried out to eluci-date the mechanism of such lubricant actions. The state of lubricated powders was followed by measuring apparent density of the powders, and by observing them with an electron microscope. 1) Lubricating mechanism of talc, or synthetic aluminum silicate is a diffusion phenomenon or diffusion-adhesion phenomenon of the lubricant particles to particles of pharmaceutical powder. In the case of calcium stearate, the lubricating mechanism is considered to consist of two phenomena; diffusion-adhesion phenomenon and trasformation-coating phenomenon of calcium stearate particles to particles of pharmaceutical powder. Namely, at the first state of lubricant-mixing, the diffusion-adhesion mainly occured, and after that, with increase of cumulative revolution number of the mixer, the transformation-coating phenomenon of calcium stearate adhered to particle surface of pharmaceutical powder occurred. 2) In the operation of mixing and lubricating pharmaceutical powder with calcium stearate in V-type mixer, the relationship between changing rate of apparent density of the powder and cumulative revolution number of the mixer is exponential and fits well the experimental equation 2.
社団法人日本薬学会の論文
1970-09-25