Decrease in Intrinsic Viscosity of Polyvinylpyrrolidone in the Presence of Sodium Chondroitin Sulfate or Sodium Carboxymethylcellulose in an Aqueous Solution

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Intrinsic viscosity and cloud point of an aqueous solution of polyvinylpyrrolidone (PVP) were measured as a function of the concentration of another added polymer, sodium carboxymethylcellulose (NaCMC) or sodium chondroitin sulfate (Na_2Chs). The intrinsic viscosity of PVP decreased with increase in the concentration of NaCMC or Na_2Chs owing to the volume effect of the polymer coils. The intrinsic viscosity of NaCMC or Na_2Chs decreased more remarkably in the presence of PVP K-90 (M.W.=1.19×10^6) than in the presence of PVP K-30 (M.W.=4.20×10^4) because the volume effect of polymer coils of PVP K-90 was stronger than that in the case of PVP K-30. The cloud point of an aqueous solution of PVP decreased with increase in the concentration of another added polymer (Na_2Chs or NaCMC) and inorganic salt (Na_2CO_3) because the polymer coils of PVP shrank and the affinity of PVP for water decreased with increase in the concentrations of these additives.
公益社団法人日本薬学会の論文
1989-10-25