Surface Tension of Aqueous Solutions of Prostaglandins and Related Unsaturated Fatty Acids

概要

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The surface properties of prostaglandins F_<2a>, E_2,D_2,A_2 and B_2 at the air-water interface were studied under conditions where these compounds are stable. Our values of critical micelle concentrations (cmc) of prostaglandins F_<2a>, E_2,A_2 and B_2 at pH 7.80 were 2.7×10^<-2>, 1.3×10^<-2>, 8.8×10^<-3> and 6.2 ×10^<-3> mol・dm^<-3>, respectively, whereas the formation of micelles at pH 4.96 was not detected for any of the prostaglandins tested. The cmc for prostaglandin D_2 could not be determined due to the instability of the compound at pH 7.80. However, the surface behavior of prostaglandin D_2 at pH 4.96 was very similar to that of prostaglandin E_2,indicating that prostaglandin D_2 may have a value of cmc at pH 7.80 close to that of prostaglandin E_2. These values of prostaglandins are comparable to those of sodium decyl sulfate, dodecanoic acid and tetradecyl phosphate. Possible structures of prostaglandins at the air-water interface and probable mechanisms of membrane penetration and permeation are discussed.
公益社団法人日本薬学会の論文
1986-02-25