Interaction of Hydroxyapatite with Sodium Chondroitin Sulfate and Calcium Chondroitin Sulfate in an Aqueous Plase
スポンサーリンク
概要
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The suspension pH at a given concentration of hydroxyapatite (HPA) decreased with the concentration of calcium chondroitin-6-sulfate (CaChs), whereas it increased with the concentration of sodium chondroitin-6-sulfate (Na_2Chs). The former effect is due to the increase in the concentration of H^+ by ion exchange between H^+ on the surface of HAP and Ca^<2+> of CaChs, and the latter is due to the protonation of phoshate ion (Pi) released from the surface of HAP. The adsorbed amount of chondroitin-6-sulfate anion (Chs) by HAP was higher with CaChs than with Na_2Chs over the concentration range examined. The equilibrium concentration of Pi decreased with increasing concentration of added CaChs because the concentration of free Ca^<2+>, which dissociates from CaChs, regulated the free concentration of Pi through the restriction of the solubility product of HAP(K_<sp>). In contrast, than in the presence of Na_2Chs increased with increasing concentration of added Na_2Chs owing to the anion exchange between Chs and Pi of the HAP surface. The total concentration of Ca^<2+>, which was released from HAP into the solution phase, increased after passing through a minimum with increasing concentration of added Na_2Chs. That is, the concentration of Ca^<2+> free from Chs decreased with an increase in the concentration of released Pi owing to the restriction of the solubility product, whereas that of Ca^<2+> bound by Chs increased with increasing concentration of added Na_2Chs through the ion exchange of Na^+ with Ca^<2+>. It was confirmed by the dialysis method that the value of K_<sp> was almost constant around 10^<-115>, although HAP dissolves incongruently in the presence of Na_2Chs.
- 公益社団法人日本薬学会の論文
- 1989-06-25
著者
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嶋林 三郎
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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糸井 恭子
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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