exo-Adduct Predominance in the Diels-Alder Reaction of Novel 1,3-Bis-(trimethylsiloxy) cyclohexa-1,3-dienes with Acrylonitrile
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概要
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The Diels-Alder reaction of the novel 1,3-bis (trimethylsiloxy) cyclohexa-1,3-dienes (3a-3c) with acrylonitrile followed by hydrolysis afforded the exo-2-cyano-1-hydroxybicyclo [2. 2. 2] octanes (4a-4c) and the endo-2-cyano-1-hydroxybicyclo [2. 2. 2] octanes (5a-5c) as the major and the minor adducts, respectively. The configuration of the cyano group of the adducts were inferred from the nuclear magnetic resonance spectral inspections of the appropriate derivatives obtained from the adducts and these assignments of the adducts (4a, 4b, 5a, and 5b) were supported by chemical evidence.
- 社団法人日本薬学会の論文
- 1978-02-25
著者
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犬伏 康夫
Faculty of Pharmaceutical Sciences, Kyoto University
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井深 俊郎
Faculty of Pharmaceutical Sciences, Kyoto University
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森 裕二
Faculty Of Pharmaceutical Sciences Kyoto University
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井深 俊郎
Faculty Of Pharmaceutical Sciences Kyoto University
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青山 利孝
Faculty of Pharmaceutical Sciences, Kyoto University
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犬伏 康夫
Faculty Of Pharmaceutical Sciences Kyoto University
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青山 利孝
Faculty Of Pharmaceutical Sciences Kyoto University
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