Isolation and Structural Investigation of the Fluorescent Degradation Products of Ampicillin
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概要
- 論文の詳細を見る
The reaction mechanism of the degradation of ampicillin to fluorescent products has been investigated. High performance liquid chromatography (HPLC) analysis of the degradation products obtained by reaction in the presence of mercuric chloride indicated the formation of a new fluorophore. Isolation of the product followed by spectral investigation showed the structure of the new fluorophore to be 2-hydroxy-3-phenyl-6-penillomethylpyrazine. The degradation in the presence of acetoaldehyde, however, produced another fluorophore which was identified as 2-hydroxy-3-phenyl-6-ethylpyrazine. The reaction mechanism was elucidated in terms of a penilloaldehyde intermediate on the above results.
- 社団法人日本薬学会の論文
- 1981-05-23
著者
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政田 幹夫
Faculty of Pharmaceutical Sciences, Setsunan University
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政田 幹夫
Department Of Hospital Pharmacy Fukui Medical School
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宇野 豊三
Faculty of Pharmaceutical Sciences, Kyoto University
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中川 照真
Faculty of Pharmaceutical Sciences, Kyoto University
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宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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政田 幹夫
福井医科大学附属病院薬剤部
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黒田 義弘
Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida
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黒田 義弘
Faculty Of Pharmaceutical Sciences Kyoto University
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宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
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宇野 豊三
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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