Common Ion Effect of Chloride on the Dissolution Properties of Papaverine Hydrochloride
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概要
- 論文の詳細を見る
The effect of chloride ion on the dissolution properties of papaverine-HCl was studied. The solubility and dissolution rate of papaverine-HCl were decreased by the common ion effect in a medium rich in chloride ion. The effect of chloride ion on the plasma levels of papaverine-HCl was also tested in rats, and lower plasma levels were observed when the drug was administered with 0.9% NaCl than in its absence. The results suggest that it may be possible to formulate sustained release preparations of papaverine-HCl by combination with NaCl.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
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宮崎 正三
東日本学園大学薬学部
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灘井 種一
Faculty of Pharmaceutical Sciences, Setsunan University
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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灘井 種一
Faculty Of Pharmaceutical Sciences Setsunan University
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灘井 種一
Faculty Of Pharmaceutical Science Josai University
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大柴 みどり
Faculty of Pharmaceutical Sciences, Josai University
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大柴 みどり
Faculty Of Pharmaceutical Sciences Josai University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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