Drug-carrier Property of Albumin Microspheres in Chemotherapy. II. Preparation and Tissue Distribution in Mice of Microsphere-entrapped 5-Fluorouracil

概要

論文の詳細を見る
Bovine serum albumin microspheres contatining 5-fluorouracil-6-^3H were prepared by heating at 180° (or 150°, 100°) of 25% albumin solution in cottonseed oil emulsion. The shape of this microsphere was invariably spherical, and the average diameter was 0.66μ. After intravenous injection in mice, 5-fluorouracil-6-^3H entrapped in albumin microspheres localized mainly in the liver, and the disappearance rate of radioactivity in microspheres from the tissue was very slow in comparison with that of free drugs. The microsphere might be delivered into reticuloendothelial system in the liver because ofits phagocytic activity, as well as the distribution following injection of albumin macroaggregates. Such preferential localization and sustained release of entrapped drugs suggested that albumin microspheres are useful as drug-carrier in chemotherapy.
公益社団法人日本薬学会の論文
1979-01-25