ウサギ耳介静脈を用いた静脈内投与抗菌剤の溶解量変更に伴う血管障害性に関する研究

概要

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We continuously injected 9 antimicrobial drugs (Viccillin^[○!R], Penicillin^[○!R], Unasyn-S^[○!R], Pansporin^[○!R], Cefmetazon^[○!R], Rocephin^[○!R], Sulperazon^[○!R], Flumarin^[○!R], Fosmicin-S^[○!R]) intravenously into the rabbit pinna vein. For the dissolution of the drugs, we used a 0.9% isotonic sodium chloride as the physiological saline solution in a volume of either 50mL or 100 mL. We conducted pathological examinations consisting of number of white blood cells (WBC), production of the C-reactive protein (CRP) and vascular lesion characteristics of the pinna vein as a means of determining the appearance of adverse reactions. There was no significant change in these pathological indications between before and after administration of the solutions, and there were no histological changes. This suggested that a change in volume of physiological saline used for dissolution from the usual 100 mL to 50 mL causes no problems in solubility.
日本医療薬学会の論文
2006-07-10