Interaction of Drugs with Bile Components. I. Effects of Bile Salts on the Dissolution Behavior of Indomethacin and Phenylbutazone
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概要
- 論文の詳細を見る
The effects of bile salts on the dissolution behavior of indomethacin and phenylbutazone were investigated. Bile salts such as sodium desoxycholate and sodium cholate considerably enhanced the dissolution of both drugs in pH 7.3 buffer at 37°. The results indicated that the enhancement of the dissolution of indomethacin in the presence of bile salts was mainly due to micellar solubilization. On the other hand, the enhanced dissolution of phenylbutazone may be due to the wetting effect, increasing the effective surface area of the powder.
- 公益社団法人日本薬学会の論文
- 1979-10-25
著者
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井上 ひとみ
Faculty Of Pharmaceutical Science Josai University
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宮崎 正三
東日本学園大学薬学部
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灘井 種一
Faculty of Pharmaceutical Sciences, Setsunan University
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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山平 智浩
Faculty of Pharmaceutical Science, Josai University
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灘井 種一
Faculty Of Pharmaceutical Sciences Setsunan University
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灘井 種一
Faculty Of Pharmaceutical Science Josai University
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山平 智浩
Research Center, Taisho Pharmaceutical Co., Ltd.,
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山平 智浩
Research Center Taisho Pharmaceutical Co. Ltd.
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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