Antitumor Effect of Implanted Ethylene-Vinyl Alcohol Copolymer Matrices Containing Anticancer Agents on Ehrlich Ascites Carcinoma and P388 Leukemia in Mice
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概要
- 論文の詳細を見る
Ethylene-vinyl alcohol (EVAI) copolymer was evaluated as a vehicle for controlled or sustained release of 5-fluorouracil (5-FU) and adriamycin. The variation of initial drug concentration and, to an even greater extent, the variation in comonomer ratio affected the drug release rate as well as the cumulative amount of the drug released. An increase in the ethylene content of the EVAI copolymer decreased drug release. It appears that EVAI copolymer can be used as a membrane for controlling the release of 5-FU or adriamycin. The antitumor activity of EVAI copolymer matrices containing these anticancer agents was evaluated against Ehrlich ascites carcinoma (EAC) in mice on the basis of changes in body weight and animal survival data. Tumor cell injections were performed on day 0 and matrix implantations on day 3,both intraperitoneally. The suppressive effect of matrices containing anticancer agents on the increase in body weight was higher than that of the free drugs. A prolongation of the life span of tumor-bearing mice following implantation of therapeutic matrices was also noted. Implantation of the EVAI copolymer matrix containing an anticancer agent was less effective against the P388 leukemia than the EAC. These results suggest that EVAI copolymer matrices containing anticancer agents may be effective in cancer chemotherapy. Matrices composed of EVAI copolymer could be useful vehicles for implanted delivery systems for anticancer agents.
- 公益社団法人日本薬学会の論文
- 1985-06-25
著者
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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侯 恵民
上海医薬工業研究院
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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橋口 典生
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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小林 博
北海道大学脳神経外科:癌研究施設病理部門
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細川 真澄男
Cancer Research Institute School Of Medicine University Of Hokkaido
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横内 千鶴子
Faculty of Pharmaceutical Science, Higashi-Nippon Gakuen University
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橋口 典生
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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侯 恵民
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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竹内 繁美
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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古賀 勇隆
Cancer Research Institute, School of Medicine, University of Hokkaido
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小林 博
Cancer Research Institute, School of Medicine, University of Hokkaido
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横内 千鶴子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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古賀 勇隆
Cancer Research Institute School Of Medicine University Of Hokkaido
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竹内 繁美
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University:(present Address)lederle (japan)
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小林 博
Cancer Research Institute School Of Medicine University Of Hokkaido
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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