Dissolution Behavior of Prednisolone from Solid Dispersion Systems with Cyclodextrins and Polyvinylpyrrolidone
スポンサーリンク
概要
- 論文の詳細を見る
Solid dispersion systems of prednisolone-cyclodextrins (CD) and prednisolone-polyvinyl-pyrrolidone (PVP) were prepared by the spray-drying method. The dissolution rates of prednisolone were markedly increased in these solid dispersion systems in the pharmacopeial disintegration medium at pH 6.8. In particular, the solid dispersion systems of prednisolone-CD inhibited and/or retarded the crystallization of prednisolone. The interaction of prednisolone with CD and PVP in water was also investigated. The apparent stability constants of the β- and γ-CD systems were both larger than that of the PVP system.
- 社団法人日本薬学会の論文
- 1986-03-25
著者
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関川 彬
北海道医療大学薬学部製剤学教室
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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関川 彬
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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剣持 晴美
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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樋口 尚代
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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剣持 晴美
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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福田 直美
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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大野 雅子
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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関川 彬
北海道医療大学 薬学部免疫微生物学教室
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関川 彬
Faculty Of Pharmaceutical Sciences Hokkaido University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
北海道医療大 薬
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大野 雅子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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樋口 尚代
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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福田 直美
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
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