Sustained Release of Sulfamethizole, 5-Fluorouracil, and Doxorubicin from Ethylcellulose-Polylactic Acid Microcapsules
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概要
- 論文の詳細を見る
The preparation of ethylcellulose-polylactic acid microcapsules with long release half-lives of chemotherapeutic agents was investigated. The microcapsules were prepared by means of coacervation-phase separation of ethylcellulose from ethyl acetate solution by nonsolvent addition in the presence of polylactic acid. In the case of sulfamethizole microcapsules, longer release half-life was obtained with larger amounts of polylactic acid in the preparation. The release rate of sulfamethizole was not very dependent on the pH of the release media. 5-Fluorouracil and doxorubicin hydrochloride were similarly microencapsulated. 5-Fluorouracil microcapsules were sieved prior to release studies. A release half life of 2.6 hr was obtained with the 5-fluorouracil microcapsules. In the case of doxorubicin microcapsules, the drug was released with a half-life of 84 min, whereas uncoated doxorubicin dissolved completely within 15 min.
- 公益社団法人日本薬学会の論文
- 1980-04-25
著者
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従二 和彦
Faculty of Pharmaceutical Sciences, Hokkaido University
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関川 彬
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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関川 彬
Faculty Of Pharmaceutical Sciences Hokkaido University
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伊藤 めぐみ
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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中野 真汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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