Sustained Release of Drugs from Ethylcellulose Microcapsules Containing Drugs dispersed in Matrices
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概要
- 論文の詳細を見る
The use of ethylcellulose microcapsules possessing a reservoir system to achieve sustained release of sulfamethizole or 5-fluorouracil was examined in vitro. As a first step, the drugs were dispersed in cellulose acetate matrices, then the matrices were microencapsulated by means of coacervation-phase separation of ethylcellulose from diethyl ether solution by nonsolvent addition. The surfaces of microcapsules were rounded, whereas the milled matrices were sharp-edged. In microcapsules of both drugs, longer release half-lives were obtained than with the corresponding matrices.
- 公益社団法人日本薬学会の論文
- 1980-09-25
著者
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伊藤 めぐみ
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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中野 真汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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