The Effect of Charges on Permeabilities of Drugs through Collagen Membranes
スポンサーリンク
概要
- 論文の詳細を見る
Permeabilities of acetaminophen, bucolome (5-n-butyl-1-cyclohexyl-2,4,6-trioxo-perhydropyrimidine), salicylic acid, aminopyrine, sulfamethizole, sulfisomidine, and p-aminobenzoic acid through a collagen membrane were measured at different pH values. The effect of pH of the media on permeation of acetaminophen, an unionizable drug in the pH range studied, was minor. Drugs in molecular form permeated faster than those in ionic form. Amphoteric drugs in cationic form permeated slower than those in corresponding anionic form. Little effect of charges of the drug molecules was observed on drug permeation through a cellophane membrane.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
-
有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
-
有田 隆一
Department Of Pharmacy Hokkaido University Hospital
-
有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
-
中野 真汎
Faculty of Pharmaceutical Sciences, Hokkaido University
-
有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
-
朽木 彰
Faculty of Pharmaceutical Sciences, Hokkaido University
-
朽木 彰
Pharmaceuticals Research Center Kanebo Ltd.
関連論文
- 高速液体クロマトグラフィーによる血漿中クロナゼパム定量法
- Determination of Triethylenetetramine in Plasma of Patients by High-Performance Liquid Chromatography
- Transformation and Excretion of Drugs in Biological Systems. IX. Interactions between Sulfinpyrazone and Sulfonamides, and between Oxyphenbutazone and Sulfonamides in Dogs
- Transformation and Excretion of Drugs in Biological Systems. VIII. Interactions between 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydro-pyrimidine and Sulfonamides in Dogs
- Transformation and Excretion of Drugs in Biological Systems. VII. Effect of Biotransformation on Renal Excretion of Sulfonamides
- Transformation and Excretion of Drugs in Biological Systems. VI. Correlation between Renal Excretion and Biotransformation of Sulfisomidine and Sulfamethizole
- Transformation and Excretion of Drugs in Biological Systems. V. Correlation between Renal Excretion and Biotransformation of Sulfadimethoxine
- Effect of Pyrazolone Derivatives on the Critical Micelle Concentration of Ionic Surfactants
- Solubilities of Antipyrine Derivatives in Water and Non-polar Solvents
- Permeation and Hydrolysis of Trichloroethyl Phosphate in the Rat Intestine
- Trichloroethyl Phosphate のラット消化管内における加水分解挙動
- Fluorometric Determination of Cephalexin, Cephradine, and Cephatrizine in Biological Fluids
- パルミチン酸クロラムフェニコールー結晶セルロース混合粉砕物の物理化学的性質と消化管吸収
- アセメタシンの消化管内挙動と胆汁排泄
- Phenylisopropyl-p-phenylenediamineの体内動態
- 溶解性,吸収性を改良した新しいジフェニルヒダントイン剤 (抗けいれん剤の発達薬理)
- Drug-carrier Property of Albumin Microspheres in Chemotherapy. II. Preparation and Tissue Distribution in Mice of Microsphere-entrapped 5-Fluorouracil
- Solubility Characteristics of Weak Bases and Their Hydrochloride Salts in Hydrochloric Acid Solutions
- Transformation and Excretion of Drugs in Biological Systems. XI. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (3)
- Transformation and Excretion of Drugs in Biological Systems. X. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (2)
- Transformation and Excretion of Drugs in Biological Systems. I. Renal Excretion Mechanisms of Sulfonamides. (I)
- N, N'-Diphenyl-p-phenylenediamineの体内動態
- 抗酸化剤の研究 : (第4報)ω, ω′-Bis-p-aminophenol誘導体の合成ならびにその抗酸化性
- Sustained Release of Dibucaine from Konjac Gels after Rectal Administration to Rats
- Effect of Formulation Additives on the Dissolution Behavior of Tetracycline Antibiotics
- Solution and Partition Behaviors of Colchicine
- Fluorometric Determination of Cephalexin in Urine
- The Effect of Charges on Permeabilities of Drugs through Collagen Membranes
- Effect of Additives on the Polymorphic Transformation of Chlortetracycline Hydrochloride Crystals
- Polymorphic Transformation of Chlortetracycline Hydrochloride Crystals Studied by Infrared Spectrophotometric Method
- A Comparison of Solubility Characteristics of Free Bases and Hydrochloride Salts of Tetracycline Antibiotics in Hydrochloric Acid Solutions
- Effect of Crystal Forms on the Dissolution Behavior and Bioavailability of Tetracycline, Chlortetracycline, and Oxytetracycline Bases
- Sustained Release of Theophylline from Konjac Gels
- The Permeation of Benzodiazepines through Synthetic Membranes
- Interactions of Aluminum, Magnesium, and Calcium Ions with Nalidixic Acid
- Spectrophotometric Studies on Accelerated Hydrolysis of Iodine In the Presence of Polyvinylpyrrolidone
- Change in Apparent Permeability of Iodine in the Presence of Polyvinylpyrrolidone
- Analysis of Permeation Profiles of Drugs from Systems containing Micelles
- Controlled Release of Butamben (Buryl p-aminobenzoate) through Silicone Membrane by Means of Complexation and Micellar Solubilization
- Controlled Drug Permeation. II. Comparative Permeability and Stability of Butamben and Benzocaine
- Physical Properties of Pyrimidine and Purine Antimetabolites. II. Permeation of 5-Fluorouracil and 1-(2-Tetrahydrofuryl)-5-fluorouracil through Cellophane, Collagen, and Silicone Membranes
- Physical Properties of Pyrimidine and Purine Antimetabolites. I. The Effects of Salts and Temperature on the Solubility of 5-Fluorouracil, 1-(2-Tetrahydrofuryl)-5-fluorouracil, 6-Mercaptopurine, and Thioinosine
- Metabolism of Thiamphenicol and Comparative Studies of Its Urinary and Biliary Excretion with Chloramphenicol in Various Species
- Sustained Release of Drugs from Ethylcellulose Microcapsules Containing Drugs dispersed in Matrices
- Sustained Release of Sulfamethizole, 5-Fluorouracil, and Doxorubicin from Ethylcellulose-Polylactic Acid Microcapsules
- Effect of Complex Formation on the Intestinal Absorption of Tryptophan
- Studies on Molecular Interaction of Organic Molecules in Solution. I. Effects of Solvent on Molecular Interaction of Salicylic Acid with Caffeine
- Effect of Conformation of Molecules on Molecular Interaction. II. Nicotinamides and Pyridine Esters
- Absorption and Excretion of Drugs. XXXIV. An Aspect of the Mechanism of Drug Absorption from the Intestinal Tract in Rats
- Absorption and Excretion of Drugs. XXXIII. The Correlation between the Absorption of Barbituric Acid Derivatives from the Rat Small Intestine and Their Binding to the Mucosa
- Absorption and Excretion of Drugs. XXXII. Absorption of Barbituric Acid Derivatives from Rat Small Intestine.
- Absorption and Excretion of Drugs. XXXI. On the Relationship between Partition Coefficients and Chemical Structures of Barbituric Acid Derivatives.
- Absorption and Excretion of Drugs. XXX. Absorption of Barbituric Acid Derivatives from Rat Stomach.
- Further Investigation on the Interaction of Sulfonamides with Non-steroidal Anti-inflammatory Agents in Dogs
- Dissolution Behavior and Gastrointestinal Absorption of Sulfamethoxazole from Sulfamethoxazole-Polyvinylpyrrolidone Coprecipitates
- Dissolution Behavior and Gastrointestinal Absorption of Dicumarol from Solid Dispersion Systems of Dicmarol-Polyvinylpyrrolidone and Dicumarol-β-Cyclodextrin
- Influence of Dietary Components on the Bioavailability of Phenytoin
- Dissolution Mechanisms of Drug-Polyvinylpyrrolidone Coprecipitates in Aqueous Solution
- Effects of Macromolecular Additives and Urea on the Intestinal Absorption of Acetaminophen in Rats
- Dissolution Behaviors and Gastrointestinal Absorption of Tolbutamide in Tolbutamide-Polyvinylpyrrolidone Coprecipitate
- Dissolution Behaviors and Gastrointestinal Absorption of Phenytoin in Phenytoin-Polyvinylpyrrolidone Coprecipitate
- Method for Optical Resolution of Racemic Homochlorcyclizine and Comparison of Optical Isomers in Antihistamine Activity and Pharmacokinetics
- Studies on the Pharmaceutical Potentiation of Drugs. I. p-Aminosalicylic Acid Derivatives.
- Application of the Cloud Point Method to the Study of the Interaction of Polyvinylpyrrolidone with Some Organic Compounds in Aqueous Solution
- テトラサイクリンの数種の固相の物性と消化管吸収
- スルホンアミド類の胆汁排泄(第1報)スルファジメトキシンの胆汁排泄
- Effect of Polymorphism on the Dissolution Behavior and Gastrointestinal Absorption of Chlortetracycline Hydrochloride
- Studies on Percutaneous Absorption of Drugs. III. Percutaneous Absorption of Drugs through Damaged Skin
- Chemical Assay of Thiamphenicol and Chloramphenicol
- Studies on Percutaneous Absorption of Drugs. II. Time-Course of Cutaneous Reservoir of Drugs
- Transformation and Excretion of Drugs in Biological Systems. IV. Reabsorption of Biliary Metoclopramide-N^4-glucuronide and -N^4-sulfonate from Rabbit Intestine
- Transformation and Excretion of Drugs in Biological Systems. III. Separatory Determination of Metoclopramide and Its N^4-Glucuronide and N^4-Sulfonate in Rabbit Urine and Bile
- 抗酸化剤の研究(第3報) : ω, ω′-Bis(2(3 or 4)-hydroxyphenyl)alkane類およびω, ω′-Bis-(2-hydroxy-3(4 or 5)-methylphenyl)alkane類の合成ならびにその抗酸化性
- 抗酸化剤の研究(第2報) : ω, ω′-Bis(2,5-dihydroxyphenyl)alkane類およびω, ω′-Bis(2-hydroxy-5-methoxyphenyl)alkane類の合成ならびにその抗酸化性
- 抗酸化剤の研究 : (第1報)ω, ω′-Bis(2,3,4-trihydroxyphenyl)alkane類の合成ならびにその抗酸化性
- Release Characteristics of Nifedipine Sustained-Release Granules in Vitro and in Healthy Subjects(Pharmaceutical)
- Studies on Percutaneous Absorption of Drugs. I.
- スルフイソキサゾールーポリビニルピロリドン共沈物の溶解性と消化管吸収
- Inhibitory Effect of Polyvinylpyrrolidone on the Crystallization of Drugs
- A Comparison of Bioavailability of Free Bases and Hydrochloride Salts of Chlortetracycline, Demethylchlortetracycline, and Methacycline
- Hydrolytic and Associative Behavior of Aromatic Amides in Aqueous Solution
- Effect of First-Pass Metabolism on Enantioselective Pharmacokinetics after Oral Administration of (+)-, (-)- and Racemic Homochlorcyclizine to Rats
- Transformation and Excretion of Drugs in Biological Systems. II. Transformation of Metoclopramide in Rabbits
- Simultaneous Vascular and Luminal Perfusion of Rat Small Intestine
- 体液中濃度測定に基づいた薬物療法の管理と適正化 : 病態時における薬物移行動態および血中濃度モニタリングと薬物投与管理 : 「薬物の体液中濃度測定と処方設計」(病院薬局協議会)
- Intestinal Absorption of Several β-Lactam Antibiotics. II. Absorption Characteristics of Amino-penicillins and Amino-cephalosporins
- Fluorometric Determination of Amoxicillin
- Intestinal Absorption Mechanisms of Ampicillin Derivatives in Rats. I. Intestinal Absorption of Ampicillin Derivatives
- Fluorometric Determination of Ampicillin and Aminobenzylpenicilloic Acid in Presence of Pivampicillin in Body Fluids
- Fluorometric Determination of Ampicillin
- 医薬品の吸収と排泄に関する研究(第28報) : 油脂溶液からのサルファ剤の直腸吸収
- Absorption and Excretion of Drugs. XXII. Absorption of Isoniazid and its Derivatives
- Studies on the Pharmaceutical Potentiation of Drugs. II. p-Aminosalicylic Acid Derivatives.
- 1-Cyclohexyl-5-n-Butyl-2,4,6-trioxoperhydropyrimidineのタンパク結合
- Absorption and Excretion of Drugs. XXVII. Effect of Nonionic Surface-Active Agents on Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXVI. Effect of Water-Soluble Bases on Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXV. On the Mechanism of Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXI. Some Pharmacokinetic Aspects of Absorption and Excretion of Sulfonamides. (3). Excretion from the Kidney.
- Absorption and Excretion of Drugs. XX. Some Pharmacokinetic Aspects of Absorption and Excretion of Sulfonamides. (2). Absorption from Rat Small Intestine.
- Absorption and Excretion of Drugs. XIX. Some Pharmacokinetic Aspects of Absorption and Excretion of Sulfonamides. (1). Absorption from Rat Stomach.