Transformation and Excretion of Drugs in Biological Systems. VI. Correlation between Renal Excretion and Biotransformation of Sulfisomidine and Sulfamethizole

概要

論文の詳細を見る
Sulfisomidine, sulfamethizole and their biotransformed products in man (N^4-acetate, N^4-glucuronide, N^4-sulfonate) were applied to renal clearance experiments in dogs and protein binding experiments to dog plasma protein in order to elucidate their renal excretion mechanisms. Clearance ratio of N^4-acetate of both sulfonamides were less than that of original sulfonamides. From the results of inhibitory experiments by iodopyracet, it was found that both sulfonamides and their N^4-acetates were actively secreted and N^4-glucuronides exhibited reduced proximal tubular secretion. It was observed that clearance ratio of sulfamethizole-N^4-glucuronide, in spite of the reduced affinity for plasma protein and increased solubility, were lower than that of sulfamethizole.
社団法人日本薬学会の論文
1971-05-25