Transformation and Excretion of Drugs in Biological Systems. IX. Interactions between Sulfinpyrazone and Sulfonamides, and between Oxyphenbutazone and Sulfonamides in Dogs
スポンサーリンク
概要
- 論文の詳細を見る
Interactions between sulfinpyrazone and sulfonamides, and between oxyphenbutazone and sulfonamides, were investigated in dogs. The plasma level of sulfamethizole, sulfamethizole-N^4-acetate and sulfisomezole-N^4-acetate were prolonged by coadministration of sulfinpyrazone or oxyphenbutazone. But no alteration was observed in plasma level patterns of sulfisomezole and sulfanilamide. Sulfinpyrazone and oxyphenbutazone possess some displacing activity towards sulfonamides bound to dog plasma proteins. In renal clearance experiments, the clearance ratios of sulfamethizole, sulfamethizole-N^4-acetate, and sulfisomezole-N^4-acetate were markedly decreased after sulfinpyrazone infusion. The effect of oxyphenbutazone on sulfonamide excretion was relatively small compared with that of sulfinpyrazone, and oxyphenbutazone remarkably decreased the clearance ratio of sulfamethizole only. It became clear that prolongations of plasma levels of the certain sulfonamides by SPZ or OPB, are mainly caused by competitive interactions between the certain sulfonamides and the two anti-inflammatory drugs at renal secretory level.
- 社団法人日本薬学会の論文
- 1974-03-25
著者
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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藤本 幸一
Pharmacy, Hokkaido University Hospital
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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三沢 絢子
Pharmacy, Hokkaido University Hospital
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藤本 幸一
Pharmacy Hokkaido University Hospital
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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三沢 絢子
Pharmacy Hokkaido University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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