Interactions of Aluminum, Magnesium, and Calcium Ions with Nalidixic Acid
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概要
- 論文の詳細を見る
Interaction of nalidixic acid with aluminum ion was revealed by spectrophotometric study. Stoichiometry of the nalidixic acid-aluminum ion complex was estimated to be 3 to 1 by the method of continuous variations. The interaction was further supported by an increase in solubility of the drug with increasing concentration of aluminum ion, by a decrease in (carbon tetrachloride/acetate buffer, pH3.3) partition coefficient with increasing concentration of aluminum ion in the aqueous layer, and by a decrease in the permeation rate of the drug through a cellulose membrane in the presence of aluminum ion in the donor compartment. Interaction of nalidixate anion with magnesium and calcium ions was also shown spectrophotometrically.
- 公益社団法人日本薬学会の論文
- 1978-05-25
著者
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中野 眞汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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山本 正和
Faculty of Pharmaceutical Sciences, Hokkaido University
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山本 正和
Faculty Of Pharmaceutical Sciences Hokkaido University
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