Application of the Cloud Point Method to the Study of the Interaction of Polyvinylpyrrolidone with Some Organic Compounds in Aqueous Solution

概要

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Polyvinylpyrrolidone (PVP) aqueous solution exhibited coacervation by addition of some inorganic salts and organic compounds. The cloud point of PVP K-90 solution appeared by addition of the least amount of ammonium sulfate, among PVP K-15,K-30 and K-90. Effect of some aromatic compounds on the cloud point of PVP aqueous solution containing ammonium sulfate was investigated. The extent of the aromatic compounds to lower the cloud point of PVP solution differed depending upon their functional groups, number of their substituents, and mutual position of the substituents. Urea derivatives elevated the cloud point, its extent being increased with the number of substituted methyl groups. Thiourea derivatives, on the other hand, lowered the cloud point. The order of the compounds to lower the cloud point was in parallel with the order of extent of interaction studied by the equilibrium dialysis method.
公益社団法人日本薬学会の論文
1978-08-25