Studies on Molecular Interaction in Solution. III. Salting Behavior of Cyclic Amides and Cyclic Conjugated Ketones in Tetraalkylammonium Salt Solutions
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概要
- 論文の詳細を見る
Salting behavior of alkylxanthines, other cyclic amides, and cyclic conjugated ketones was investigated by the solubility, partition, and permeation methods. These compounds were found to be salted-out by tetramethyl-and tetraethylammonium salts against the common belief that nonelectrolytes are salted-in by these salts. The above compounds were, however, salted-in by large ammonium salts and the effect was attributed to complex formation between the large ammonium ions and the nonelectrolytes. Salts were also shown to affect equilibrium concentrations of nonelectrolytes across a lipoid membrane and the rate of permeation of nonelectrolytes through the membrane.
- 公益社団法人日本薬学会の論文
- 1970-04-25
著者
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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光長 孝義
Faculty of Pharmaceutical Sciences, Kyoto University
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光長 孝義
Formulation Research Department Ibaraki Plant Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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中野 真汎
Pharmaceutical Chemistry Division, Research Laboratories, Food and Drug Directorate
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