Preparation and Evaluation in Vitro of Polycarbonate Microspheres Containing Local Anesthetics
スポンサーリンク
概要
- 論文の詳細を見る
To achieve sustained release of local anesthetics from injectable formulations, polycarbonate microspheres were prepared by a solvent-evaporation process. Release patterns of benzocaine, lidocaine, and dibucaine from polycarbonate microspheres in vitro were investigated. Drug contents and sizes of microspheres affected the release patterns of the local anesthetics. The release rate of drugs from smaller microspheres was greater than that from larger microspheres, and with increase in the drug contents, the release rate increased. Microspheres before and after release studies were observed by scanning electron microscopy. It was confirmed that the use of polycarbonate microspheres resulted in sustained release of local anesthetics.
- 公益社団法人日本薬学会の論文
- 1984-07-25
著者
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児島 強
熊本大学医学部附属病院 治験支援センター
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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従二 和彦
城西大・薬
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吉田 泰彦
東洋大工
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従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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従二 和彦
Department of Pharmacy, Kumamoto University Hospital
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井上 祥平
Department Of Synthetic Chemistry Faculty Of Engineering University Of Tokyo
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児島 強
Department of Pharmacy, Kumamoto University Hospital
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吉田 泰彦
Department of Applied Chemistry, Faculty of Engineering, Tohyo University
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吉田 泰彦
東洋大
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吉田 泰彦
Department Of Applied Chemistry Faculty Of Engineering Tohyo University
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児島 強
熊本大学医学部附属病院薬剤部
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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