Plasma Levels of Tegafur Following Implantation of Polycarbonate Pellets Containing Tegafur or FD-1 into Rats
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概要
- 論文の詳細を見る
The possible use of poly (ethylene carbonate) and poly (propylene carbonate) pellets for sustained release of 5-fluorouracil derivatives (tegafur and FD-1) has been examined in vivo. Plasma levels of tegafur following implantation of the polycarbonate pellets into the rat peritoneal cavity were determined by high pressure liquid chromatography. Sustained release of the drug was obtained over 50d following implantation of poly (propylene carbonate) pellets containing 40% FD-1. Plasma level profiles in vivo were compared with release profiles in vitro. Plasma level profiles with multiple peaks were observed following implantation of FD-1 in poly (propylene carbonate) pellets and tegafur in poly (ethylene carbonate) pellets.
- 公益社団法人日本薬学会の論文
- 1983-11-25
著者
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従二 和彦
城西大・薬
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吉田 泰彦
東洋大工
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川口 健夫
Faculty of Pharmaceutical Sciences, Josai University
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従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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従二 和彦
Department of Pharmacy, Kumamoto University Hospital
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中野 真汎
Department of Pharmacy, Kumamoto University Hospital
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川口 健夫
Faculty Of Pharmaceutical Sciences Josai University
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井上 祥平
Department Of Synthetic Chemistry Faculty Of Engineering University Of Tokyo
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吉田 泰彦
Department of Applied Chemistry, Faculty of Engineering, Tohyo University
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吉田 泰彦
東洋大
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吉田 泰彦
Department Of Applied Chemistry Faculty Of Engineering Tohyo University
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