Stability, Specific Binding Activity, and Plasma Concentration in Mice of an Oligodeoxynucleotide Modified at 5'-Terminal with Poly (ethylene glycol)

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概要

• 論文の詳細を見る

• Oligodeoxynucleotide (ODN) composed of 15 nucleotides was modified at 5'-terminal phosphate with hexylamine linker and chemically activated poly (ethylene glycol). This derivative showed improved characteristics in terms of enzymatic stability, binding activity, and in vivo retention in mouse. The data are discussed in comparison with those of corresponding unmodified and phosphorothioate ODNs.

• 公益社団法人日本薬学会の論文
• 1995-03-15

著者

• 田代 康壽貴

  城西大学薬学部

• 川口 健夫

  Faculty of Pharmaceutical Sciences, Josai University

• Juni Kazuhiko

  Faculty Of Pharmaceutical Sciences Josai University

• 從二 和彦

  Faculty Of Pharmaceutical Sciences Josai University

• 浅川 浩樹

  Department Of Bacteriology Okayama University Medical School

• 浅川 浩樹

  Faculty of Pharmaceutical Sciences, Josai University

• 田代 康壽貴

  Faculty of Pharmaceutical Sciences, Josai University

• 末石 俊彦

  Faculty of Pharmaceutical Sciences, Josai University

• 川口 健夫

  Faculty Of Pharmaceutical Sciences Josai University

• 川口 健夫

  城西大学

• 末石 俊彦

  Faculty Of Pharmaceutical Sciences Josai University

• 浅川 浩樹

  Faculty Of Pharmaceutical Sciences Josai University

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