Nasal Absorption of 2', 3'-Didehydro-3'-deoxythymidine (D4T) and Its Esters in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Nasal absorption of 2', 3'-didehydro-3'-deoxythymidine (D4T) and its esters (5'-acetyl D4T : C2-D4T and 5'-hemisuccinyl D4T : Suc-D4T) was investigated in rats. Bioavailability of D4T following intranasal (i.n.) administration was 98.0%, and the elimination from plasma was as rapid as that following intravenous administration of D4T. There seemed to be complete and rapid absorption of D4T from the nasal cavity. The plasma concentration-time profile of D4T following i.n. administration of C2-D4T was almost the same as that after administration of D4T itself. This suggests that C2-D4T was rapidly absorbed from the nasal cavity, and that some amount of dosing C2-D4T was hydrolyzed to D4T before entering the systemic circulation. In contrast, Suc-D4T showed slower absorption in the i.n. administration, and the plasma D4T level was maintained for a long period.
- 公益社団法人日本薬学会の論文
- 1996-09-15
著者
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長谷川 哲也
城西国際大学 薬学部
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SANEYOSHI MINEO
Department of Biological Sciences, Teikyo University of Sciences and Technology
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Juni Kazuhiko
Faculty of Pharmaceutical Sciences, Josai University
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Juni K
Faculty Of Pharmaceutical Sciences Josai University
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Juni Kazuhiko
北海道薬科大学
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Juni Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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KAWAGUCHI Takeo
Faculty of Pharmaceutical Sciences, Josai University
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HASEGAWA Tetsuya
Faculty of Pharmaceutical Sciences, Josai University
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Hasegawa T
Univ. Tokushima School Of Medicine Tokushima Jpn
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YAJIMA Toshiyuki
Faculty of Pharmaceutical Sciences, Josai University
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Saneyoshi Mineo
城西大学 薬
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Saneyoshi Mineo
Department Of Biological Science Teikyo University Of Science And Technology
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Hasegawa Tetsuya
Faculty Of Pharmaceutical Sciences Chiba University
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川口 健夫
城西大学
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Yajima T
Pharmaceutics Laboratory Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Hasegawa Tetsuya
Faculty Of Pharmaceutical Science Josai International University
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Yajima T
Department Of Pharmaceutics Research Center Taisho Pharmaceutical Co. Ltd.
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