Cytotoxicity and Pharmacokinetics of 1-β-D-Arabinofuranosyl-2-thiocytosine, a 2-Sulphur Substituted Derivative of Cytarabine

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概要

• 論文の詳細を見る

• 1-(β-D-Arabinofuranosyl)-2-thiocytosine (araSC), a 2-substituted derivative of cytarabine (araC), has been investigated for its cytotoxicity, enzymatic stability, plasma concentration-time profile in mice, and cytokinetics.This derivative showed strong cytotoxicity in several mammalian cell lines, although activity (IC_<50>s) was weaker than araC. Greater stability to mouse cytidine deaminase was observed; the half-line in the presence of the enzyme was about 4-times longer than that of araC. The plasma concentration-time profile in mice in vivo showed prolonged retention of araSC when compared with araC. Cytokinetic study using flow cytometry indicated a non-S-phase specific effect of this compound.

• 公益社団法人日本薬学会の論文
• 1999-01-15

著者

• HASEGAWA Tetsuya

  Department of Management and Information Science, Kyushu School of Engineering, Kinki University

• Kawaguchi Takeo

  Department of Cardiology, Odawara Municipal Hospital

• 長谷川 哲也

  城西国際大学 薬学部

• SANEYOSHI MINEO

  Department of Biological Sciences, Teikyo University of Sciences and Technology

• YUKITA Ayako

  Tsukuba Research Laboratory, Toagousei Co., Ltd.

• ASANO Makoto

  Tsukuba Research Laboratory, Toagousei Co., Ltd.

• Hasegawa T

  Univ. Tokushima School Of Medicine Tokushima Jpn

• NAGATA Toshiyuki

  Tsukuba Research Laboratory, Toagosei Co., Ltd.,

• ICHIKAWA Tomohisa

  Department of Pharmaceutical Sciences, Josai University

• WAKAYAMA Toshiyuki

  Tsukuba Research Laboratory, Toagosei Co., Ltd.,

• KATO Hisatoyo

  Tsukuba Research Laboratory, Toagosei Co., Ltd.,

• 市川 智久

  城西大学薬学部

• Saneyoshi Mineo

  城西大学 薬

• Saneyoshi Mineo

  Department Of Biological Science Teikyo University Of Science And Technology

• Hasegawa Tetsuya

  Department Of Chemistry The University Of Tokyo

• 川口 健夫

  城西大学

• Asano Makoto

  Bioscience Research Department Tsukuba Research Laboratory Toagosei Co. Ltd.

• Kawaguchi Takeo

  Department Of Cardiology Odawara Municipal Hospital

• Hasegawa Tetsuya

  Department Of Chemistry Graduate School Of Science The University Of Tokyo

• Hasegawa Tetsuya

  Department Of Applied Chemistry Himeji Institute Of Technology

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