Acyclothymidine Alleviates Intestinal Toxicity of 5'-Deoxy-5-fluorouridine without Loss of Antitumor Activity in Mice
スポンサーリンク
概要
- 論文の詳細を見る
To reduce the intestinal toxicity of orally administered 5'-deoxy-5-fluorouridine (5'-DFUR) in mice, we co-administered 5'-DFUR with acyclothymidine [AcyT, 5-methyl-(2'-hydroxyethoxymethyl) uracil], a potent inhibitor of pyrimidine nucleoside phosphorylase (PyNPase). Orally administered 5'-DFUR alone caused intestinal toxicity and severe damage to the intestinal villi, while 5'-DFUR with AcyT reduced the intestinal toxicity, and prevented damage to the intestinal villi. This toxicity arising from orally administered 5'-DFUR could not be reduced by intravenous administration of AcyT, but was alleviated by oral administration. Orally co-administered AcyT showed little effect on antitumor activity of 5'-DFUR toward subcutaneously implanted Lewis lung carcinoma, though the intestinal toxicity was reduced in the tumor-bearing mice. This finding suggests that orally co-administered AcyT may prevent the undesirable conversion of 5'-DFUR to 5-FU by PyNPase during the process of absorption in the intestinal tract.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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Hamada Akinobu
熊本大学医学部附属病院 薬剤
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Hamada Akinobu
Kumamoto Univ. Hospital Kumamoto Jpn
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Hamada Akinobu
Department Of Pharmacy Kumamoto University Hospital
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NAKANO Masahiro
Department of Physics, Kyoto University
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SANEYOSHI MINEO
Department of Biological Sciences, Teikyo University of Sciences and Technology
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Nakano M
Department Of Information Science University Of Occupational And Environmental Health
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Fukushima Shoji
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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SHIMIZU Satoshi
Faculty of Pharmaceutical Sciences, Josai University
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KAWAGUCHI Takeo
Faculty of Pharmaceutical Sciences, Josai University
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Nakano M
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Saneyoshi Mineo
城西大学 薬
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Saneyoshi Mineo
Department Of Biological Science Teikyo University Of Science And Technology
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Fukushima Shoji
Department Of Pharmacy Kumamoto University Hospital
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Fukushima Shoji
Faculty Of Pharmaceutical Science Kobe Gakuin University
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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川口 健夫
城西大学
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Nakano M
Univ. Occupational And Environmental Health Jpn
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Shimizu Satoshi
Faculty Of Dairy Science Rakuno Gakuen University
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Nakano Masahiro
Deparment Of Physics Kyushu University
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